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Statistical tests supported this observation, and the trim and fill model did not identify any missing studies, further validating the robustness of the findings regarding FBS change

CD4 T cells exhibited potent interactions with monocytes, NK cells, and T cells, and these interactions were diminished by L-serine (Fig

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By contrast, serine itself is an allosteric inhibitor of PHGDH, and this allosteric inhibition can spontaneously disappear at low serine levels (Sugimoto and Pizer, 1968)

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This appeared necessary because G6PD5.4-OFP did not co-localize with GFP-PGD2 (Supplementary Figure S6A), but OFP-PGD2 showed weak overlap with GFP-PGL2 (Supplementary Figure S6B)